By Thomas Lengauer, Raimund Mannhold, Hugo Kubinyi, Hendrik Timmerman
Presents a wide, application-oriented evaluate of this know-how. The cutting-edge in bioinformatics is evaluated both from an international view through introducing actual program eventualities.
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Additional resources for Bioinformatics. From Genomes to Drugs
Modeling threedimensional structures of RNA is basically an unsolved problem, however, there are eective methods for modeling two-dimensional RNA structures. We do not discuss modeling RNA structures in this book and refer the reader to . 3 Proteins Proteins display a wide variety of structures. The protein structure prediction problem has been a challenge for a long time. Many successes have been accomplished but the general problem is still far from being solved. What can be achieved is to model (target) proteins given a structurally resolved protein that acts as a template.
This paradigm of searching for target proteins in genomics data is considered to be so promising that pharmaceutical industry has been investing heavily in it in over the past years. Contracts between pharmaceutical companies and new biotech industry that is providing the data and clues to new targets have involved hundreds of million dollars. In turn, each new target protein can aord a completely new approach to disease therapy and a potentially highly lucrative worldwide market share. Yet, the paradigm still has to prove its value.
The genome sequence of Drosophila melanogaster, Science, 2000. 287(5461): p. 2185±95. Huynen, M. , Y. Diaz-Lazcoz, and P. Bork, Dierential genome display, Trends Genet, 1997. 13(10): p. 389±90. 1 Introduction Although a theoretical method to predict the three-dimensional structure of a protein from its sequence alone is not in sight yet, researchers have uncovered a multitude of connections between the primary sequence on one hand and various functional features of proteins on the other hand.
Bioinformatics. From Genomes to Drugs by Thomas Lengauer, Raimund Mannhold, Hugo Kubinyi, Hendrik Timmerman