Download e-book for iPad: Amyloid precursor protein : a practical approach by Weiming Xia, Huaxi Xu

By Weiming Xia, Huaxi Xu

ISBN-10: 0849322456

ISBN-13: 9780849322457

Within the look for an efficient remedy for Alzheimer's disorder, APP is a special version protein that illustrates the big range of simple and complex characterization innovations to be had.

Exploring numerous organic strategies to elucidate the constitution and serve as of this transmembrane protein, this article provides each one approach with targeted, step by step protocols to accomplish reproducible effects and supply a framework for learning different membrane proteins.

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Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells. J. Cell Biol. 97, 508, 1983. 18. Beisiegel, U. et al. Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia. J. Biol. Chem. 256, 11923, 1981. 19. H. et al. Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody.

Et al. The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site. Structure 6, 109, 1998. 30. J. et al. Solution structure of the heparin-binding domain of vascular endothelial growth factor. Structure 6, 637, 1998. 31. U. et al. From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells. Proc. Natl. Acad. Sci. USA 95, 1770, 1998. 32. A. C. Amyloid precursor protein modulates the interaction of nerve growth factor with p75 receptor and potentiates its activation of trkA phosphorylation.

Linear regression is used to determine the initial velocity (V0) of the uninhibited enzyme. fm Page 43 Wednesday, November 3, 2004 3:20 PM the development of potent HIV inhibitors has been successful using peptide-based in vitro enzyme assays. Thus it is likely that memapsin 2 inhibitors with pharmaceutical application for modulation of Aβ production may be developed from the assay of small peptide substrates that model the fundamental proteolytic function, superseding the complexity of the memapsin 2 function in vivo.

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Amyloid precursor protein : a practical approach by Weiming Xia, Huaxi Xu


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