Adult Stem Cell Therapies: Alternatives to Plasticity - download pdf or read online

By Mariusz Z. Ratajczak

ISBN-10: 1493910000

ISBN-13: 9781493910007

ISBN-10: 1493910019

ISBN-13: 9781493910014

This well timed quantity explores numerous concepts for tissue and organ regeneration utilizing stem cells remoted from grownup tissues. It discusses substitute causes of stem mobilephone plasticity in addition to present scientific effects with grownup stem mobilephone remedies. It examines the presence of power pluripotent stem cells in grownup tissues, paracrine results of stem mobilephone remedies, and involvement of exosomes and microparticles into saw phenomena. Fifteen chapters, all written through famous leaders in their fields, specialize in quite a few issues together with twine blood and hematopoietic stem cells, pores and skin and tissue organ regeneration, very small embryonic-like stem cells, and mobilephone cures in cardiology, neonatology, and neurology. Edited through Dr. Mariusz Ratajczak, an across the world recognized professional in grownup stem cellphone biology, Adult Stem cellphone cures: choices to Plasticity is a vital addition to the Stem mobilephone Biology and Regenerative Medicine series.

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Extra info for Adult Stem Cell Therapies: Alternatives to Plasticity

Example text

A growing body of evidence suggests that MVs secreted, for example, from HSPCs, MSCs, ASCs, NSCs, or CSCs employed in various treatment strategies efficiently inhibit apoptosis of cells residing in the damaged tissues, stimulate their proliferation, and promote vascularization [66, 67, 72, 73]. , VEGF or SCF) on their surface, and (3) deliver mRNA, regulatory miRNA, and proteins that improve overall cell function [32, 33, 65]. In 26 M. Kucia et al. Fig. 2 Beneficial effects of hematopoietic stem cells ( HSCs), mesenchymal stem cells ( MSCs), or cardiac stem cells ( CSCs) in regenerative medicine using heart infarct as a model.

Ragina NP, Schlosser K, Knott JG, Senagore PK, Swiatek PJ, Chang EA et al (2012) Downregulation of H19 improves the differentiation potential of mouse parthenogenetic embryonic stem cells. Stem cells Dev 21:1134–1144 62. Janowska-Wieczorek A, Majka M, Ratajczak J, Ratajczak MZ (2001) Autocrine/paracrine mechanisms in human hematopoiesis. Stem Cells 19:99–107 63. Ratajczak J, Kijowski J, Majka M, Jankowski K, Reca R, Ratajczak MZ (2003) Biological significance of the different erythropoietic factors secreted by normal human early erythroid cells.

J Cell Sci 117:2971–2981 26. Kucia M, Wojakowski W, Reca R, Machalinski B, Gozdzik J, Majka M et al (2006) The migration of bone marrow-derived non-hematopoietic tissue-committed stem cells is regulated in an SDF-1-, HGF-, and LIF-dependent manner. Arch Immunol Ther Exp 54:121–135 27. Kucia M, Halasa M, Wysoczynski M, Baskiewicz-Masiuk M, Moldenhawer S, Zuba-Surma E et al (2007) Morphological and molecular characterization of novel population of CXCR4+SSEA-4+Oct-4+ very small embryonic-like cells purified from human cord blood: preliminary report.

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Adult Stem Cell Therapies: Alternatives to Plasticity by Mariusz Z. Ratajczak

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